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Preface >
Sunitinib Malate is the drug being marketed as Sutent which
was earlier popular as SU11248, is the small molecular
receptor tyrosine kinase reducer which is used for the
treatment of gastrointestinal stromal tumor (GIST) and renal
cell carcinoma (RCC). Sutent minimizes signaling through
multiple tyrosine receptor including platelet-derived growth
factor receptor and vascular endothelial growth factor
receptor. Sutent is used to treat the advanced stage of
kidney cancer when the medicine called Gleevec which is
Imanitib Mesylate, is not capable of stopping cancer from
growing further or in case just you cannot take it any more.
Sutent has been granted authentic approval by the United
States Foods and Drugs Administration only on 26th of
January 2006.
Usage of Sutent
> Sutent capsules are made in 12.5 mg, 25 mg and 50 mg
strengths by the world’s largest pharmaceutical producers
Pfizer Inc. Sutent is primarily used for patients with GIST
who disease succession during earlier imatinib treatment or
for them who did not bear imatinib. One of the clinical
trials of its patient population, the time to succession was
considerably longer in the SUETENT than the placebo arm.
Dose
mechanism > Dose reduction and/or addition of
antihypertensive or diuretic therapy may be needed; however,
impulsive recovery has also been noticed. The patients may
require to be monitored for symptoms of congestive heart
failure and STUTENT may have to be stopped under the
circumstances. Sutent capsule should be taken by mouth and it can be taken
with or without food. When your doctor suggests Sutent for
you, better try to avoid grapefruit juice for that day. The
dosage of Sutent that you will receive depends on several
factors including your general health or other health
problems and the type of cancer or condition you have. It is
your doctor who will determine the exact dosage and schedule
for you.
Sutent (generic name: sunitinib) is a targeted therapy and
is a receptor protein-tyrosine kinase inhibitor. Sutent
inhibits the actions of vascular endothelial growth factor
and is an angiogenesis inhibitor. Sutent is used for the
treatment of gastrointestinal stromal tumor (GIST) and also
for the treatment of advanced renal cell cancer.
Sutent Side
Effects > Clinical studies have noticed several side
effects of this drug like: diarrhoea, hypertension, skin
discoloration, mucositis, fatigue and hypothyroidism.
Most common side effects of taking Sutent (occurring in
greater than 30%) include: Heartburn, taste changes,
fatigue, diarrhea, nausea and vomiting, hypertension, low
blood counts.Some other important drugs are
simvastatin,
androz, slimona,
orlistat and
finasteride
Less common side effects of taking Sutent (occurring in
29-10%) include: Dry skin, swelling of ankles and feet,
dizziness, increased amylase and lipase levels, shortness of
breath, generalized aches and pains, rash, flatulence,
hand–foot syndrome such as skin rash, swelling, redness,
pain and/or peeling of the skin on the palms of hands and
soles of feet, dehydration, low potassium levels, increased
bilirubin levels, hair color changes, cough, hair loss, poor
appetite, headache, increased liver enzymes, weakness,
constipation, abdominal pain, bleeding and fever etc.
Rare side effects (occurring in 2-3%) include problems with
blood clots. |
